Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†

Human Endometrial Receptivity and Embryo- Endometrium Interactions

Infertility is an increasing medical and social problem affecting more than 10% of couples worldwide. Many underlying causes of human infertility have been overcome by assisted reproductive techniques; nevertheless, the implantation process remains one of the rate-limiting step as regards the success of the treatment. A prerequisite for successful implantation is the adequate preparation of a r...

Endometrial Receptivity to Embryo Implantation: Molecular Cues from Functional Genomics

The endometrium is the mucous lining the uterine cavity comprised of a basal and a functional layer being the latter the one that sheds during menses and regenerates from the basal portion. The main cell populations within the functional stratus are epithelial and stromal cells accompanied by a variable number of leukocytes. Epithelial cells are found covering the luminal surface and tubular gl...

Adiponectin Effect on The Viability of Human Endometrial Stromal Cells and mRNA Expression of Adiponectin Receptors

Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity.

The aim of the present prospective study was to obtain quantitative data on endometrial volume by three-dimensional (3D) ultrasound at the time of embryo transfer in an in-vitro fertilization programme and to assess its value in predicting endometrial receptivity. The cycles (n = 72) were classified according to endometrial volume: group A <2 ml, group B 2-4 ml, and group C >4 ml. Comparisons o...

Angiogenesis Following Three-Dimensional Culture of Isolated Human Endometrial Stromal Cells

Background Endometriosis is the presence of endometrial tissue outside of the uterine cavity and is the most common gynecologic disorder in women of reproductive age. We have preliminary evidence that in the presence of a 3-dimensional (3-D) fibrin matrix, human endometrial glands, stroma, and neovascularization can develop in vitro, mimicking the earliest stages of endometriosis. The aim of th...